Metabolic Research

5-Amino-1MQ

Name: 5-Amino-1MQ
Brand: Ventra Sciences
Availability: InStock

CAS 685079-15-6 Research Use Only

A small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor used in studies of NAD+ salvage, adipocyte metabolism, and cellular energy-signaling research. For laboratory research use only.

Dosage

Quantity

$50.00

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U.S.-synthesized & shipped

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Compound Information

Technical specifications

Molecular Profile

What is this compound?

Type: Nicotinamide N-methyltransferase (NNMT) inhibitor (small molecule)
CAS Number: 685079-15-6
Molecular Weight: 159.21 g/mol
Formula: C10H11N2+
Sequence: Quinolinium small molecule; not a peptide

PubChem Database

Storage Requirements

Stability Information

Protect from light Temperature-sensitive

Lyophilized (powder) -20°C · stable long-term

In solution 2-8°C · protect from light

Sources & References

Peer-reviewed research

Biochemical pharmacology

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

2018 PMID 29155147 DOI 10.1016/j.bcp.2017.11.007

Neelakantan H, Vance V, Wetzel MD, et al.

View on PubMed

Scientific reports

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

2022 PMID 35013352 DOI 10.1038/s41598-021-03670-5

Dimet-Wiley A, Wu Q, Wiley JT, et al.

View on PubMed

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells

2021 PMID 33645410 DOI 10.1080/01443615.2020.1854696

Akar S, Duran T, Azzawri AA, et al.

View on PubMed

References are provided for qualified researchers as a starting point for literature review. Ventra Sciences makes no claims about the contents of cited works.

5-Amino-1MQ is a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), supplied as a lyophilized powder for in vitro laboratory research use only. It is studied in the peer-reviewed literature as a chemical probe of the NNMT/NAD+ salvage axis, and is investigated in research models for its role in adipocyte metabolic signaling and cellular energy homeostasis pathways.

Product Description

1-methylquinolinium derivative carrying a 5-amino substitution; a small molecule, not a peptide
Characterized in the literature as a cell-permeable inhibitor of NNMT (nicotinamide N-methyltransferase)
Investigated for its relationship to the NAD+ salvage pathway and cellular methylation balance
Studied in preclinical adipocyte and skeletal-muscle metabolic models
Frequently referenced in the metabolic and NAD+ research literature

Research Use Notes

Supplied as lyophilized powder in a sealed vial
Requires reconstitution before use; Amino H2O sold separately
Appearance: white to off-white lyophilized powder or cake
Identity and purity verified by third-party COA

Storage & Handling

Store the sealed lyophilized vial frozen (-20C) and protected from light
Keep refrigerated (2-8C) once reconstituted
Reconstituted material has a limited stability window; handle per your laboratory's SOP

Intended Use:

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not for human or veterinary use and must not be used in food, drugs, diagnostics, or cosmetics.

Disclaimer:

This compound has not been evaluated by the FDA.
It is not intended to diagnose, treat, cure, or prevent any disease.
All use must comply with applicable institutional, local, and federal regulations.

Terms of Sale:

By purchasing from Ventra Sciences, the buyer affirms they are a qualified researcher or institution.
All sales are final. The purchaser assumes full responsibility for handling, use, and regulatory compliance.

Research applications: Commonly used in NNMT enzyme-inhibition studies, NAD+ salvage-pathway research, and metabolic-signaling research applications.

For laboratory research use only. Not a drug, cosmetic, supplement, or food. Not for human or animal consumption.

This product is intended strictly for in vitro laboratory research by qualified professionals. It is not for human or veterinary use and must not be used in food, drugs, diagnostics, or cosmetics. Ventra Sciences makes no medical claims regarding any compound sold. All purchasers acknowledge they will use this product solely for research purposes.