Neuro Research

Dihexa

CAS 1401708-83-5 Research Use Only

An angiotensin IV-derived compound studied in the literature for its role in hepatocyte growth factor / c-Met receptor signaling and synaptogenesis research. For laboratory research use only.

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Quantity
$70.00
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Compound Information

Technical specifications

Molecular Profile

What is this compound?

Type
Angiotensin IV-derived HGF/c-Met modulator
CAS Number
1401708-83-5
Molecular Weight
504.7 g/mol
Formula
C27H44N4O5
Sequence
N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
PubChem Database
Storage Requirements

Stability Information

Protect from light Temperature-sensitive
Lyophilized (powder) -20°C · stable long-term
Reconstituted 2-8°C · use within 28 days

Sources & References

Peer-reviewed research

The Journal of Pharmacology and Experimental Therapeutics
The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
2014 PMID 25187433 DOI 10.1124/jpet.114.218735
Benoist CC, Kawas LH, Zhu M, et al.
View on PubMed
Brain Sciences
AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway
2021 PMID 34827486 DOI 10.3390/brainsci11111487
Sun X, Deng Y, Fu X, et al.
View on PubMed
Journal of Alzheimer's Disease
The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease
2015 PMID 25649658 DOI 10.3233/JAD-142814
Wright JW, Harding JW
View on PubMed

References are provided for qualified researchers as a starting point for literature review. Ventra Sciences makes no claims about the contents of cited works.

Dihexa is a small angiotensin IV-derived compound, supplied as a lyophilized powder for in vitro laboratory research use only. It is characterized in the peer-reviewed literature as a hepatocyte growth factor (HGF) mimetic that acts through the HGF/c-Met receptor system, and is investigated in research models of synaptogenesis and cognitive neuroscience.

Product Description

  • Small peptidomimetic derived from the angiotensin IV sequence
  • Reported in the literature to potentiate hepatocyte growth factor (HGF) signaling at the c-Met receptor
  • Studied for synaptogenesis and dendritic spine formation in preclinical neural models
  • Characterized as notably lipophilic relative to native angiotensin peptides
  • Frequently referenced in the neurotrophic-signaling research literature

Research Use Notes

  • Supplied as lyophilized powder in a sealed vial
  • Requires reconstitution before use; Amino H2O sold separately
  • Appearance: white to off-white lyophilized powder
  • Identity and purity verified by third-party COA

Storage & Handling

  • Store the sealed lyophilized vial frozen (-20C), protected from light
  • Keep refrigerated (2-8C) once reconstituted
  • Reconstituted material has a limited stability window; handle per laboratory SOP

Intended Use:

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not for human or veterinary use and must not be used in food, drugs, diagnostics, or cosmetics.

Disclaimer:

This compound has not been evaluated by the FDA.
It is not intended to diagnose, treat, cure, or prevent any disease.
All use must comply with applicable institutional, local, and federal regulations.

Terms of Sale:

By purchasing from Ventra Sciences, the buyer affirms they are a qualified researcher or institution.
All sales are final. The purchaser assumes full responsibility for handling, use, and regulatory compliance.

Research applications: Commonly used in HGF/c-Met receptor signaling studies, synaptogenesis research, and neuroplasticity research applications.

For laboratory research use only. Not a drug, cosmetic, supplement, or food. Not for human or animal consumption.

This product is intended strictly for in vitro laboratory research by qualified professionals. It is not for human or veterinary use and must not be used in food, drugs, diagnostics, or cosmetics. Ventra Sciences makes no medical claims regarding any compound sold. All purchasers acknowledge they will use this product solely for research purposes.

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