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Endocrine / Growth Research

Ventra GN-1

Name: Ventra GN-1
Brand: Ventra Sciences
SKU: VSC-GN1
Price: 75.00 USD
Availability: InStock

VSC-GN1Research Use Only

A heterodimeric glycoprotein hormone of the gonadotropin family, studied in the literature for its structural biology and its role in LHCGR receptor-signaling research. For laboratory research use only.

Dosage

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$75.00

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U.S.-synthesized & shipped

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Compound Information

Technical specifications

Molecular Profile

What is this compound?

Ventra GN-1 is human chorionic gonadotropin (hCG), a heterodimeric glycoprotein hormone supplied as a lyophilized powder for in vitro laboratory research use only. It is assembled from two non-covalently associated subunits: a 92-amino-acid alpha chain common to the glycoprotein hormone family, and a 145-amino-acid beta chain that confers receptor specificity. Both chains are extensively glycosylated, and because that carbohydrate content is heterogeneous, potency is expressed in International Units rather than by mass. It is characterized in the peer-reviewed literature as a ligand of the LH/choriogonadotropin receptor (LHCGR) and is among the most structurally well-resolved glycoprotein hormones, with published crystal and cryo-EM structures.

Research applications: Commonly used in glycoprotein-hormone structural research, LHCGR receptor-signaling studies, and analytical characterization research applications.

Type: Heterodimeric glycoprotein hormone; alpha chain 92 aa (UniProt P01215), beta chain 145 aa (UniProt P0DN86)
Molecular Weight: 36 kDa (approximate; carbohydrate content is heterogeneous, so potency is expressed in International Units rather than by mass)

Storage Requirements

Stability Information

Protect from lightTemperature-sensitiveFragile glycoprotein

Lyophilized (powder)-20°C · stable long-term

Reconstituted2-8°C · use within 30 days

Sources & References

Peer-reviewed research

Nature

Crystal structure of human chorionic gonadotropin

1994PMID 8202136DOI 10.1038/369455a0

Lapthorn AJ, Harris DC, Littlejohn A, et al.

View on PubMed

Nature

Structures of full-length glycoprotein hormone receptor signalling complexes

2021PMID 34552239DOI 10.1038/s41586-021-03924-2

Duan J, Xu P, Cheng X, et al.

View on PubMed

Scientific Reports

Human Luteinizing Hormone and Chorionic Gonadotropin Display Biased Agonism at the LH and LH/CG Receptors

2017PMID 28424471DOI 10.1038/s41598-017-01078-8

Riccetti L, Yvinec R, Klett D, et al.

View on PubMed

Journal of Pharmaceutical and Biomedical Analysis

First profiling in hydrophilic interaction liquid chromatography of intact human chorionic gonadotropin isoforms

2019PMID 31234040DOI 10.1016/j.jpba.2019.06.014

Camperi J, Pichon V, Fournier T, et al.

View on PubMed

References are provided for qualified researchers as a starting point for literature review. Ventra Sciences makes no claims about the contents of cited works.

For research use only

This product is intended strictly for in vitro laboratory research by qualified professionals. It is not for human or veterinary use and must not be used in food, drugs, diagnostics, or cosmetics. Ventra Sciences makes no medical claims regarding any compound sold. All purchasers acknowledge they will use this product solely for research purposes.

This compound has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease. All use must comply with applicable institutional, local, and federal regulations.

By purchasing from Ventra Sciences, the buyer affirms they are a qualified researcher or institution. All sales are final. The purchaser assumes full responsibility for handling, use, and regulatory compliance.