Peptide

Melanotan I

CAS 75921-69-6 Research Use Only

A synthetic 13-amino-acid analog of alpha-MSH, studied in the literature for its role in melanocortin-1 receptor (MC1R) signaling and melanogenesis research. For laboratory research use only.

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$60.00
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Compound Information

Technical specifications

Molecular Profile

What is this compound?

Type
Synthetic alpha-MSH analog (MC1R agonist)
CAS Number
75921-69-6
Molecular Weight
1646.8 g/mol
Formula
C78H111N21O19
Amino Acids
13
Sequence
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
PubChem Database
Storage Requirements

Stability Information

Protect from light Temperature-sensitive
Lyophilized (powder) -20°C · stable long-term
Reconstituted 2-8°C · use within 28 days

Sources & References

Peer-reviewed research

American journal of clinical dermatology
Afamelanotide: A Review in Erythropoietic Protoporphyria
2016 PMID 26979527 DOI 10.1007/s40257-016-0184-6
Kim ES, Garnock-Jones KP
View on PubMed
Journal of cell science
Alpha-melanocyte stimulating hormone and its analogue Nle4DPhe7 alpha-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes
1994 PMID 8175909 DOI 10.1242/jcs.107.1.205
Hunt G, Todd C, Cresswell JE, et al.
View on PubMed
ACS chemical neuroscience
Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors
2016 PMID 27135265 DOI 10.1021/acschemneuro.6b00098
Todorovic A, Ericson MD, Palusak RD, et al.
View on PubMed

References are provided for qualified researchers as a starting point for literature review. Ventra Sciences makes no claims about the contents of cited works.

Melanotan I (afamelanotide) is a synthetic linear 13-amino-acid analog of alpha-melanocyte-stimulating hormone, supplied as a lyophilized powder for in vitro laboratory research use only. It is characterized in the peer-reviewed literature as a potent melanocortin-1 receptor (MC1R) agonist with extended stability relative to native alpha-MSH, and is studied in research on melanogenesis and photoprotective signaling pathways.

Product Description

  • Linear tridecapeptide analog of alpha-melanocyte-stimulating hormone with Nle4 and D-Phe7 substitutions
  • Those substitutions confer greater enzymatic stability and receptor affinity than native alpha-MSH
  • Studied for melanocortin-1 receptor (MC1R) binding and eumelanin synthesis pathways in melanocyte cell models
  • Structurally distinct from Melanotan II, a cyclic heptapeptide with broader melanocortin receptor activity
  • Referenced in the melanocortin-receptor pharmacology literature

Research Use Notes

  • Supplied as lyophilized powder in a sealed vial
  • Requires reconstitution before use; Amino H2O sold separately
  • Appearance: white to off-white lyophilized powder
  • Identity and purity verified by third-party COA

Storage & Handling

  • Store the sealed lyophilized vial frozen (-20C), protected from light
  • Keep refrigerated (2-8C) once reconstituted
  • Reconstituted material has a limited stability window; handle per laboratory SOP

Intended Use:

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not for human or veterinary use and must not be used in food, drugs, diagnostics, or cosmetics.

Disclaimer:

This compound has not been evaluated by the FDA.
It is not intended to diagnose, treat, cure, or prevent any disease.
All use must comply with applicable institutional, local, and federal regulations.

Terms of Sale:

By purchasing from Ventra Sciences, the buyer affirms they are a qualified researcher or institution.
All sales are final. The purchaser assumes full responsibility for handling, use, and regulatory compliance.

Research applications: Commonly used in melanocortin-1 receptor signaling studies, melanogenesis research, and photoprotective-pathway research applications.

For laboratory research use only. Not a drug, cosmetic, supplement, or food. Not for human or animal consumption.

This product is intended strictly for in vitro laboratory research by qualified professionals. It is not for human or veterinary use and must not be used in food, drugs, diagnostics, or cosmetics. Ventra Sciences makes no medical claims regarding any compound sold. All purchasers acknowledge they will use this product solely for research purposes.

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