Endocrine / Growth Research

PEG-MGF

VSC-MGF5 Research Use Only

A PEGylated form of mechano growth factor (MGF), an IGF-1 splice variant E-domain peptide studied for its role in myogenic precursor cell signaling. For laboratory research use only.

Quantity
$105.00
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Compound Information

Technical specifications

Molecular Profile

What is this compound?

Type
PEGylated mechano growth factor (IGF-1Ec E-domain peptide)
Molecular Weight
2868.13 g/mol (MGF peptide; conjugate mass varies with PEG chain length)
Formula
C121H199N41O40 (MGF peptide, prior to PEG conjugation)
Amino Acids
24
Sequence
YQPPSTNKNTKSQRRKGSTFEERK (MGF / IGF-1Ec E-domain peptide, PEG-conjugated)
Storage Requirements

Stability Information

Protect from light Temperature-sensitive
Lyophilized (powder) -20°C · stable long-term
Reconstituted 2-8°C · use within 28 days

Sources & References

Peer-reviewed research

Experimental Cell Research
A new pro-migratory activity on human myogenic precursor cells for a synthetic peptide within the E domain of the mechano growth factor
2007 PMID 17156777 DOI 10.1016/j.yexcr.2006.10.032
Mills P, Lafrenière JF, Benabdallah BF, et al.
View on PubMed
PloS One
Insulin-like growth factor I (IGF-1) Ec/Mechano Growth factor--a splice variant of IGF-1 within the growth plate
2013 PMID 24146828 DOI 10.1371/journal.pone.0076133
Schlegel W, Raimann A, Halbauer D, et al.
View on PubMed
Endocrinology
Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration
2010 PMID 20130113 DOI 10.1210/en.2009-1217
Matheny RW Jr, Nindl BC, Adamo ML
View on PubMed

References are provided for qualified researchers as a starting point for literature review. Ventra Sciences makes no claims about the contents of cited works.

PEG-MGF is a polyethylene-glycol-conjugated form of mechano growth factor (MGF), the E-domain peptide of the IGF-1Ec splice variant, and is supplied as a lyophilized powder for in vitro laboratory research use only. The MGF peptide is characterized in the peer-reviewed literature for its distinct pro-migratory activity on human myogenic precursor cells, separate from mature IGF-1 signaling. The PEGylation is a formulation modification intended to extend the peptide half-life; note that published literature addresses the MGF peptide itself rather than the PEGylated conjugate specifically.

Product Description

  • MGF is a splice variant of insulin-like growth factor 1 (IGF-1Ec) with a distinct C-terminal E-domain
  • PEGylation attaches a polyethylene glycol chain, reported to extend stability in solution relative to native MGF
  • Studied for satellite-cell activation and myoblast proliferation in preclinical muscle models
  • Investigated in the mechanotransduction literature on load-induced muscle gene expression
  • Frequently studied alongside IGF-1 analogs in muscle-tissue research

Research Use Notes

  • Supplied as lyophilized powder in a sealed vial
  • Requires reconstitution before use; Amino H2O sold separately
  • Appearance: white to off-white lyophilized cake
  • Identity and purity verified by third-party COA

Storage & Handling

  • Store the sealed lyophilized vial frozen (-20C), protected from light
  • Keep refrigerated (2-8C) once reconstituted
  • Do not repeatedly freeze and thaw reconstituted material, and avoid vigorous agitation

Intended Use:

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not for human or veterinary use and must not be used in food, drugs, diagnostics, or cosmetics.

Disclaimer:

This compound has not been evaluated by the FDA.
It is not intended to diagnose, treat, cure, or prevent any disease.
All use must comply with applicable institutional, local, and federal regulations.

Terms of Sale:

By purchasing from Ventra Sciences, the buyer affirms they are a qualified researcher or institution.
All sales are final. The purchaser assumes full responsibility for handling, use, and regulatory compliance.

Research applications: Commonly used in myogenic precursor cell research, IGF-1 splice-variant signaling studies, and tissue-repair research applications.

For laboratory research use only. Not a drug, cosmetic, supplement, or food. Not for human or animal consumption.

This product is intended strictly for in vitro laboratory research by qualified professionals. It is not for human or veterinary use and must not be used in food, drugs, diagnostics, or cosmetics. Ventra Sciences makes no medical claims regarding any compound sold. All purchasers acknowledge they will use this product solely for research purposes.

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